Minimally Invasive Surgery

MIS Extreme Lateral Interbody Fusion (XLIF)

A Minimally Invasive Approach to Lumbar Fusion

Extreme Lateral Interbody Fusion (XLIF) is a type of spinal fusion performed through the patient’s side (lateral approach). Instead of making a large incision in the back, the surgeon accesses the spine through a small incision in the flank, gently moving aside muscles to reach the vertebrae and discs. At Desert Spine and Pain, we use XLIF to stabilize the spine and relieve pressure on nerves when conservative treatments have not been effective. Under the expertise of Dr. David L. Greenwald, M.D., FAANS, FACS, one of the nation’s top neurosurgeons, this approach often allows patients to experience faster recovery, less pain, and smaller incisions compared to traditional fusion.

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Over 30 Years Experience in Orthopedic & Neuro Spine Surgeries.

What Is XLIF?

  • In simple terms: XLIF fuses two vertebrae together by removing a damaged disc and placing a spacer (cage) filled with bone graft through a side incision.

  • Scientifically: The lateral transpsoas approach provides direct access to the intervertebral disc space without disrupting posterior spinal muscles. A cage packed with autograft/allograft is inserted to restore disc height and promote arthrodesis (fusion).


Conditions Treated with XLIF

  • Degenerative Disc Disease with collapse or instability

  • Spondylolisthesis (low to moderate grade)

  • Spinal Stenosis with instability

  • Recurrent disc herniation requiring stabilization

  • Post-traumatic degeneration or deformity correction


Benefits of XLIF

  • Smaller incision compared to open back fusion

  • Less muscle disruption (posterior muscles are spared)

  • Shorter hospital stay (often 1–2 days)

  • Faster recovery and return to activity

  • Excellent restoration of disc height and indirect decompression of nerves

  • Lower blood loss than traditional posterior approaches


The XLIF Procedure: Step by Step

  1. Anesthesia & positioning – General anesthesia; patient positioned on their side.

  2. Small flank incision – A 1–2 inch incision is made in the patient’s side.

  3. Navigating through muscles – Tubular retractors gently spread the psoas muscle to access the disc space.

  4. Disc removal – The damaged disc is removed.

  5. Implant placement – A cage (spacer) filled with bone graft is inserted to restore disc height and promote fusion.

  6. Stabilization – Screws, rods, or plates may be added through minimally invasive posterior incisions if needed.

  7. Closure & recovery – Incision is closed; patients often walk the same day.


Risks and Limitations

  • Nerve irritation in the psoas muscle (temporary thigh numbness/weakness possible)

  • General surgical risks: infection, bleeding, hardware issues, non-union

  • Not ideal for all levels of the spine (best for lumbar levels L1–L5)

  • Rare complications include vascular or bowel injury


Recovery Timeline

  • Day 0–1: Walking the same day or next morning

  • Weeks 2–6: Light activities; many patients return to desk work

  • Weeks 6–12: Fusion begins consolidating; activity increases with PT guidance

  • 3–6 months: Progressive return to normal life; fusion solidifying

  • 6–12 months: Complete bony fusion expected in most patients



Why Choose Desert Spine and Pain?

  • Expert neurosurgeon – Dr. Greenwald is skilled in advanced MIS fusion approaches, including XLIF

  • Patient-focused care – Thorough evaluation to determine if XLIF is the right option

  • Smaller incisions, faster recovery – Minimally invasive techniques designed to reduce fear and downtime

  • Comprehensive treatment – We combine MIS with PT, injections, and conservative care whenever possible


Frequently Asked Questions


How is XLIF different from traditional fusion?

XLIF uses a side approach instead of the back, sparing muscles and often allowing faster recovery.


Will I need rods and screws with XLIF?

Often yes. Posterior fixation adds stability and increases fusion success.


Is XLIF painful?

All surgery involves some discomfort, but XLIF typically causes less pain than open fusion.


How soon can I return to work?

Desk workers may return within 2–4 weeks; physical jobs may take 2–3 months.


How does Desert Spine and Pain perform XLIF differently?

We combine neurosurgical precision, navigation technology, and minimally invasive techniques under Dr. Greenwald’s expertise.


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Desert Spine and Pain

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Phoenix, AZ, USA

Dr. David L. Greenwald, MD

Neuro-Spine Surgeon

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October 06, 20250 min read

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Over 30 Years Experience in Orthopedic & Neuro Spine Surgeries.

Dr. David L. Greenwald, M.D., F.A.C.S.

Neurosurgeon | Spine Surgeon | Regenerative Medicine

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