Minimally Invasive Surgery
Extreme Lateral Interbody Fusion (XLIF) is a type of spinal fusion performed through the patient’s side (lateral approach). Instead of making a large incision in the back, the surgeon accesses the spine through a small incision in the flank, gently moving aside muscles to reach the vertebrae and discs. At Desert Spine and Pain, we use XLIF to stabilize the spine and relieve pressure on nerves when conservative treatments have not been effective. Under the expertise of Dr. David L. Greenwald, M.D., FAANS, FACS, one of the nation’s top neurosurgeons, this approach often allows patients to experience faster recovery, less pain, and smaller incisions compared to traditional fusion.
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In simple terms: XLIF fuses two vertebrae together by removing a damaged disc and placing a spacer (cage) filled with bone graft through a side incision.
Scientifically: The lateral transpsoas approach provides direct access to the intervertebral disc space without disrupting posterior spinal muscles. A cage packed with autograft/allograft is inserted to restore disc height and promote arthrodesis (fusion).
Degenerative Disc Disease with collapse or instability
Spondylolisthesis (low to moderate grade)
Spinal Stenosis with instability
Recurrent disc herniation requiring stabilization
Post-traumatic degeneration or deformity correction
Smaller incision compared to open back fusion
Less muscle disruption (posterior muscles are spared)
Shorter hospital stay (often 1–2 days)
Faster recovery and return to activity
Excellent restoration of disc height and indirect decompression of nerves
Lower blood loss than traditional posterior approaches
Anesthesia & positioning – General anesthesia; patient positioned on their side.
Small flank incision – A 1–2 inch incision is made in the patient’s side.
Navigating through muscles – Tubular retractors gently spread the psoas muscle to access the disc space.
Disc removal – The damaged disc is removed.
Implant placement – A cage (spacer) filled with bone graft is inserted to restore disc height and promote fusion.
Stabilization – Screws, rods, or plates may be added through minimally invasive posterior incisions if needed.
Closure & recovery – Incision is closed; patients often walk the same day.
Nerve irritation in the psoas muscle (temporary thigh numbness/weakness possible)
General surgical risks: infection, bleeding, hardware issues, non-union
Not ideal for all levels of the spine (best for lumbar levels L1–L5)
Rare complications include vascular or bowel injury
Day 0–1: Walking the same day or next morning
Weeks 2–6: Light activities; many patients return to desk work
Weeks 6–12: Fusion begins consolidating; activity increases with PT guidance
3–6 months: Progressive return to normal life; fusion solidifying
6–12 months: Complete bony fusion expected in most patients
Expert neurosurgeon – Dr. Greenwald is skilled in advanced MIS fusion approaches, including XLIF
Patient-focused care – Thorough evaluation to determine if XLIF is the right option
Smaller incisions, faster recovery – Minimally invasive techniques designed to reduce fear and downtime
Comprehensive treatment – We combine MIS with PT, injections, and conservative care whenever possible
XLIF uses a side approach instead of the back, sparing muscles and often allowing faster recovery.
Often yes. Posterior fixation adds stability and increases fusion success.
All surgery involves some discomfort, but XLIF typically causes less pain than open fusion.
Desk workers may return within 2–4 weeks; physical jobs may take 2–3 months.
We combine neurosurgical precision, navigation technology, and minimally invasive techniques under Dr. Greenwald’s expertise.
A Spine Specialist is standing by.
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Phone: (602) 566-9500
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Conditions ,Treatments Surgery &Wellness
October 06, 2025•0 min read
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